Chinese
Lab member
  
Current Location >> Lab member >> Current
Current

Qiliang Cai

Qiliang Cai, Ph.D. Professor

Key Laboratory of Molecular Medical Virology (Ministries of Education and Health)

Fudan University, School of Basic Medical Science, Shanghai, P.R.China 200032
Current Contact Info:  +8621-5423-7716
E-mail：qiliang@fudan.edu.cn

 

EDUCATION:

Ph.D. in Etiology and Immunology, July 2004

Peking Union Medical College (PUMC) &

Chinese Academy of Medical Science (CAMS) in Beijing

M.S. in Biochemistry and Molecular Biology, July 2001

National Key Laboratory of Agricultural Microbiology

Huazhong Agricultural University (HAU) in Wuhan

B.S. in Biotechnology, May 1999

College of Life Science and Technology, HAU, Wuhan

RESEARCH INTERESTS :

Epigenetic and immunological basis of Viral Cancers

Host- pathogen interactions,

Identification of unknown pathogens, Vaccine development


RESEARCH EXPERIENCE:

 

Professor   (2/2012 – present)  ¾   Tumor virology

                                              Key Laboratory of Molecular Medical Virology (Ministries of Education and Health),

Fudan University, School of Basic Medicine

Research Associate   (10/2009 – 2/2012)        ¾   Tumor virology

Department of Microbiology, University of Pennsylvania School of Medicine

Postdoctoral Fellow  (10/2004 – 10/2009)     ¾   Tumor virology

Laboratory of Professor Erle Robertson

Department of Microbiology, University of Pennsylvania School of Medicine

Molecular mechanism of DNA tumor virus-mediated oncogenesis and adaption to hypoxic stress             

Ph.D.  (9/2001-7/2004)                ¾   Parasitology & Vaccinology 

Dissertation Research (PUMC& CAMS, Beijing)

Polyepitope, artificial antigen DNA vaccine against

Plasmodium falciparum created and optimized by molecular breeding technology

M.S. (9/1998 – 7/2001)              ¾   Bacteriology

 Thesis Research (HAU, Wuhan)

Isolation and characterization of Vegative Insecticial Protein from Bacillus thuringinese


ACADEMIC HONORS:

 

Editorial board member of Chinese Society of Medical Virology, 2013

Editorial board member of Chinese Society of Microbiology in Virology, 2013

Editorial board member of National Scientific Foundation of China, 2012

Young Fellow award of National Scientific Foundation of China, 2009

Distinguished Ph.D. research fellow award in PUMC, 2004

First Prize, Scientific Thesis Advancement, Hubei Province, China, 2003

First Prize, Academic Thesis, HAU, Wuhan, China, 2002


PAPERS & PUBLICATIONS:* corresponding author）


  1. Chen WL, Jin X, Wang M, Liu D, Luo Q, Tian H, Cai L, Meng L, Bi R, Wang L, Xie X, Yu G, Li L, Dong C, Cai Q, Jia W, Wei W, Jia L. GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling. JCI Insight. 2020 Feb 13;5(3):e131596.

  2. Zhang Y, Wang Y, Zhu C, Robertson ES*, Cai Q*. Role of SUMOylation in Human Oncogenic Herpesvirus Infection. Virus Res. 2020 Jul 2;283:197962.

  3. Wang Y, Du S, Zhu C, Wang C, Yu N, Lin Z, Gan J, Guo Y, Huang X, He Y, Robertson E, Qu D, Wei F, Cai Q*.  Stub1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency. PLoS Pathog. 2020 Mar 16;16(3):e1008447.

  4. Mo X, Du S, Chen X, Wang Y, Liu X, Zhang C, Zhu C, Ding L, Li Y, Tong Y, Ju Q, Qu D, Tan F*, Wei F*, Cai Q*. Lactate induces production of the tRNAHis half to promote B-lymphoblastic cell proliferation. Mol Ther. 2020 Nov 4;28(11):2442-2457

  5. Ding L, Zhu Q, Zhou F, Tan H, Xu W, Pan C, Zhu C, Wang Y, Zhang H, Fu W, Qian Z, Xu H*, Wei F*, Cai Q*. Identification of viral SIM-SUMO2-interaction inhibitors for treating primary effusion lymphoma. PLoS Pathog, 2019, 15(12):e1008174

  6. Wan C, Tai J, Zhang J, Guo Y, Zhu Q, Ling D, Gu F, Gan J, Zhu C, Wang Y, Liu S*, Wei F*, Cai Q*, Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication. Cell Death Dis. 2019, May 21;10(6):392. doi: 10.1038/s41419-019-1624-z

  7. Li G, Ding L, Ma X, Cai Q, Ying T, Wei F. Establishment of Novel Monoclonal Fabs Specific for Epstein-Barr Virus Encoded Latent Membrane Protein 1. Virol Sin. 2019 Apr 4. doi: 10.1007/s12250-019-00103-6. 

  8. Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q*. Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis. Cell Reports. 2019, March 26, 26(13):3657-3671.

  9. Gu F, Wang C, Wei F, Wang Y, Zhu Q, Ding L, Xu W, Zhu C, Cai C, Qian Z, Yuan Z, Robertson E, Cai Q*. STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus. PLoS Pathogens. 2018 Dec 10; 14(12):e1007416

  10. Hu W, Zi Z, Jin Y, Li G, Shao K, Cai Q, Ma X, Wei F. CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions. Cancer Immunol Immunother. 2018, Dec 6. doi: 10.1007/s00262-018-2281-2.

  11. Du S, Liu X, Cai Q*. Viral-Mediated mRNA Degradation for Pathogenesis. Biomedicines. 2018, Nov 29; 6(4). pii: E111

  12. Yu W, Geng S, Suo Y, Wei X, Cai Q, Wu B, Zhou X, Shi Y, Wang B. Critical Role of Regulatory T Cells in the Latency and Stress-Induced Reactivation of HSV-1.Cell Reports. 2018, Nov 27;25(9):2379-2389

  13. Wang Y, Ding L, Zhu Q, Shu M, Cai Q*. Common Infections May Lead to Alzheimer's Disease. Virologica Sinica. 2018, Oct;33(5):456-458

  14. Ding L, Mo X, Zhang L, Zhou F, Zhu C, Wang Y, Cai C, Liu Y, Wei F, Cai Q*. High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai. Journal of Medical Virology. 2018 Sep;90(9):1532-1540

  15. Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, Tan F, Zhu C, Wang Y, Yu Q, Liu Y, Robertson ES, Yuan Z, Cai Q* (2018). Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth. Journal of Virology, Feb 14. doi: 10.1128/JVI.00033-18.

  16. Wang C, Zhu C, Wei F, Gao S, Zhang L, Li Y, Feng Y, Tong Y, Xu J, Wang B, Yuan Z, Cai Q* (2017). Nuclear translocation and cleavage of STAT6 is induced by Kaposi’s sarcoma-associated herpesvirus for viral latency. PLoS Pathogens, 13(1):e1006124.

  17. Liang Q, Wang K, Wang B*, Cai Q*(2017). HCMV-encoded miR-UL112-3p promotes glioblastoma progression via tumour suppressor candidate 3. Scientific Reports, 7:44705

  18. Editors by Cai Q*, Yuan Z, Lan K (2017). Infectious Agents Associated Cancers: Epidemiology and Molecular Biology, Springer press, eBook: DOI 10.1007/978-981-10-5765-6. p1-277

  19. Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q* (2017). The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers. Virologica Sinica, 32(5):357-368

  20. Zhu Q, Gu F, Zhu C, Wang Y, Wei F*, Cai Q*(2017). Interplay between microenvironmental abnormalities and infectious agents in tumorigenousis. Adv Exp Med Biol, 1018:253-271

  21. Zhu C, Wang Y, Cai C, Cai Q*(2017). Bacterial infection and associated Cancers. Adv Exp Med Biol, 1018:181-191

  22. Cai Q*(2017), Yuan Z. Overview of infectious causes of human cancers. Adv Exp Med Biol, 1018:1-9

  23. Liu YQ, Zhang GL, Mo XH, Wang B, Wu F, Chen J, Luo H, Zhu LD, Xu MY, Zhou Q, Cai Q*, Wang XL* (2017). A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient.  J Eur Acad Dermatol Venereol. May 18. doi: 10.1111/jdv.14344.

  24. Wei F, Gan J, Wang C, Zhu C, Cai Q* (2016). Cell-cycle regulatory functions of the KSHV oncoproteins LANA. Frontier in Microbiology, 7(334): doi 103389

  25. Wang C, Wei F, Cai Q * (2015). Deregulation of IL-4/IL-13-induced STAT6 signaling in viral oncogenesis. Oncology Communication, 1:e1131

  26. Wang C, Zhu C, Wei F, Zhang L, Mo X, Feng Y, Xu J, Yuan Z, Robertson E, Cai Q * (2015). Constitutive activation of IL-13/STAT6 contributes to KSHV-associated PEL cell proliferation and survival. Journal of Virology, 89(20):10416-10426.

  27. Gan J, Wang C, Jin Y, Guo Y, Xu F, Zhu Q, Ding L, Shang H, Wang J, Wei F*, Cai Q*, Robertson E* (2015). Proteomic profiling identifies the SIM-associated complex of KSHV-encoded LANA. Proteomics, 15(12):2023-37.

  28. Thakker S, Purushothaman P, Gupta N, Cai Q, Verma SC* (2015). KSHV LANA inhibits MHC II expression by disrupting the enhanceosome assembly through binding with the RFX complex. Journal of Virology, 89(10):5536-56.

  29. Zhang L, Zhu C, Guo Y, Wei F, Lu J, Qin J, Wang J, Verma SC, Shan H, Yuan ZH, Robertson ES*, Cai Q* (2014). Inhibition of KAP1 enhances hypoxia-induced KSHV reactivation through RBP-Jk. Journal of Virology, 88(12):6873-84.

  30. Zhang L，Zhu C，Cai Q* (2014) . Advances in the pathogenesis of hypoxia signaling mediated by human oncogenic virus. Chin J Microbe Infect, 1(1):16-23.

  31. Zhu C，Cai Q* (2013)。Impact of the hypoxic microenvironment on KSHV-mediated oncogenesis. Adv in Microbe Infect, edt. by Y Wen and Z Yuan, Book Chapter,10:1-7

  32. Cai Q*, Cai S, Zhu C, Verma SC, Choi JY, Robertson ES* (2013). A SUMO2-interacting motif within LANA is essential for KSHV latency. PLoS Pathogens, 9(10):e1003751.

  33. Cai Q*, Shuovomoy A, Cervini A, Lu J, Hislop AD, Dzeng R, Robertson ES* (2013). IRF4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation. PLoS Pathogens, 9(10):e1003750.

  34. Cai Q, Xiao B, Si H, Cervini A, Gao J, Lu J, Robertson ES (2012). Kaposi’s sarcoma herpesvirus upregulates Aurora A kinase to promote phosphorylation-dependent ubiquitylation of p53. PLoS Pathogens, 8(3): e1002566.  

  35. Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES (2011). Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. PLoS Pathogens, 7(12):e1002418.  

  36. Cai Q, Verma SC, Choi JY, Ma M, Robertson ES (2010). Kaposi’s sarcoma associated herpesvirus inhibites IL-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency. Journal of Virology, 84(21):11134-11144.

  37. Cai Q, Verma SC, Kumar P, Ma M, Robertson ES (2010). Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS ONE, 5(3): e9720.  

    (News reports about the research featured at the following links:

    http://news.pennmedicine.org/news-bites/2010/06/tumor-suppressor-protein-tag-suggests-new-therapy.html

     Recommended by Faculty of 1000 Biology:

    http://f1000biology.com/article/id/2743956/evaluation )

  38. Cai Q, Robertson ES (2010). Ubiquitin/SUMO modification regulates VHL protein stability and nucleotyoplasmic shuttling. PLoS ONE, 5(9):e12636.

  39. Cai Q, Verma SC, Lu J, Robertson ES (2010). Molecular biology of Kaposi’s sarcoma-associated herpesvirus and related oncogenesis. Advances in Virus Research, 78:87-142.(Invited review)

  40. Cai Q, Murakami M, Si H, Robetson ES (2007). A potential alpha-helix motif in theamino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia. Journal of Virology, 81(19):10413-23.

  41. Cai Q, Peng G, Bu L, Lin Y, Zhang L, Lustigmen S, Wang H (2007). Immunogenicity and in vitro protective efficacy of a polyepitope Plasmodium falciparum candidate vaccine constructed by epitope shuffling. Vaccine. 25(28):5155-65.

  42. Cai Q, Knight JS, Verma SC, Zald P, Robertson ES (2006). EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of VHL and p53 tumor suppressors. PLoS Pathogens, 2(10): e116.  

    (News reports about the research featured at the following links:

    http://www.uphs.upenn.edu/news/News_Releases/nov06/KSHV.htm

    http://www.sciencedaily.com/releases/2006/11/061108154410.htm

    http://www.med.upenn.edu/micro/whats_new_items/item104.html )

  43. Cai Q, Lan K, Verma SC, Si H, Lin D, Robertson ES (2006). Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions. Journal of Virology, 80(16):7965-75.  

  44. Cai Q, Wei F, Lin Y, Shao D, Wang H (2004). Immunogenicity of polytope library assembled by epitope shuffling: an approach to design chimeric DNA vaccine against malaria. Vaccine, 23(2):267-77.

  45. Cai Q, Wang H (2003). Gene artificial evolution by molecular breeding technology. Chin Bulletin of Life Sciences, 15(3): 183-188

  46. Cai Q, Liu Z, Yu Z (2004). Characteristic analysis of vegetative insecticidal protein gene from Bacillus thuringiensis. Chin J Biochem.Mol Biol, 20(5): 630-636

  47. Cai Q, Liu Z, Yu Z (2003). The synergism of vegetative insecticidal protein VIP and CRY protein from Bacillus thuringiensis. Chin Microbiol, 30(5): 43-48

  48. Cai Q, Liu Z, Yu Z (2003). Research review on biological active components of Bacillus thuringiensis. Chin J Appl Environ Biol, 9(2): 207-212

  49. Cai Q, Liu Z, Sun M, Wei F, Yu Z (2002). The analysis of Bacillus thuringiensis vegetative insecticical gene clone and expression. Chin J Biotech, 18(5): 578-582

  50. Banerjee S, Lu J, Cai Q, Sun Z, Jha HC, Robertson ES. EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation. PLoS Pathogens, 2014, 10(8):e1004304

  51. Banerjee S, Lu J, Cai Q, Saha A, Jha HC, Robertson ES. The EBV latent antigen 3C inhibits apoptosis through targeted regulation of interferon regulatory factors 4 and 8. PLoS Pathogens, 2013, 9(5):e1003314

  52. Jha H, Lu J, Saha A, Cai Q, Banerjee S, Mahadesh AJ, Robertson E. BNA3C-mediated regulation of Aurora Kinase B contributes to EBV-induced B-cell proliferation through modulation of the activities of Rb and apoptotic Caspases. Journal of Virology, 2013, in press

  53. Jha H, Upadhyay S, Mahadesh AJ, Lu J, Cai Q, Saha A, Robertson ES. H2AX phosphorylation is important for LANA-mediated Kaposi’s sarcoma-associated herpesvirus episome persistence. Journal of Virology, 2013, 87(9):5255-69

  54. Verma SC, Cai Q, Kreider E, Lu J, Robertson ES. Comprehensive analysis of LANA interacting proteins essential for viral genome tethering and persistence. PLoS One, 2013, e0074662

  55. Banerjee S, Jha HC, Cai Q, Robertson ES. Epstein-Barr Virus and Burkitt’s  lymphoma:An indispensable relationship. BURKITT’S LYMPHOMA, edited by Robertson ES, Springer Press. 2013 VIII, p1-32.

  56. Lu J, Verma SC,  Cai Q, Saha A, Dzeng R, Robertson ES (2011). The RBP-Jκ binding sites within the RTA Promoter Regulates KSHV Latent Infection and Proliferation. PLoS pathogens, 8(1):e1002479.

  57. Verma SC, Lu J, Cai Q, Kosiyatrakul S, McDowell M, Schildkraut CL, Robertson ES (2011). Single molecule analysis of replicated DNA reveals the usage of mutiple KSHV genome regions for latent replication. PLoS pathogens, 7(11):e1002365.

  58. Saha A, Halder S, Upadhayay S, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES (2011). EBNA3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. PLoS Pathogens, 7(2):e1001275.

  59. Lu J, Verma SC, Cai Q, Robertson ES (2011). The single RBP-Jk site within the LANA promoter is crucial for establishing KSHV latency during primary infection. Journal of Virology, 85(13):6148-6161.

  60. Gao J, Cai Q, Lu J, Jha HC, Robertson ES (2011). Upregulation of cellular Bcl-2 by the KSHV encoded RTA promotes virion production. PLoS One, 6(8):e23892.

  61. Song X, Guo W, Cui J, Qian X, Yi L, Chang M, Cai Q, Zhao Q (2011). A tritherapy combination of a fusion protein vaccine with immune-modulating doses of sequential chemotherapies in an potimized regiment completely eradicates large tumors in mice. International Journal of Cancer, 128(5):1129-38.

  62. Lu J, Murakami M, Verma SC, Cai Q, Haldar S, Kaul R, Wasik, MA, Middeldorp J, Robertson ES (2010). Epstein-Barr virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV positive B-lymphoma Cells through up-regulation of survivin. Virology, 410(1):64-75.

  63. Xiao B, Verma SC, Cai Q, Kaul R, Lu J, Saha A, Robertson ES (2010). Bub1 and CENP-F Can Contribute to KSHV Genome Persistence by Targeting LANA to Kinetochores. Journal of Virology, 84(19):9718-32.

  64. Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES (2009). Epstein-Barr virus nuclear antigen 3C targets p53 and represses its transcriptional activity. Virology, 8(1):11-19.

  65. Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES (2009). Deregulation of the cell cycle machinery by epstein-bar virus nuclear antigen 3C. Future Virology, 4(1):1-8.

  66. Verma SC, Cai Q, Bajaj B, Robertson ES (2009). Overview of the large DNA virus. DNA tumor virus, (edited by Jim P and Blossom D), Springer press, ISBN:978-0-387-68944-9. (Book Chapter 8) 

  67. Lu J, Verma SC, Murakami M, Cai Q, Kumar P, Xiao B, Robertson ES (2009). Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation. Journal of Virology, 83(14):7129-41.

  68. Bajaj, B, Murakami M, Cai Q, Verma SC, Robertson ES (2008). Epstein-Barr virus nuclear antigen 3C interacts with and enhances the stability of the c-Myc oncoprotein. Journal of Virology, 82(8):4082-90.

  69. Si H, Verma SC, Lamphson M, Cai Q, Robertson ES (2008). KSHV Encoded LANA can interact with the Nuclear Mitotic Apparatus Protein to Regulate Genome Maintenance and Segregation. Journal of Virology, 82(13):6734-46.

  70. Verma SC, Bajaj B, Cai Q, Si H, Seelhammer T, Robertson ES (2006). Latency Associated Nuclear Antigen of KSHV Recruits Uracil DNA Glycosylase 2 at the Terminal Repeats and is Important for Latent Persistence of the Virus. Journal of Virology, 80(22):11178-90.

  71. Ding J, Guo C, Cai Q, Lin Y, Wang H (2005). In vivo expression of green fluorescent

    protein gene and immunogenicity of ES312 vaccine both mediated by starburst polyamidoamine dendrimers. Acta Academiae Medicinae Sinicae, 27(4):499-503

  72. Guo C, Wang H, Lin Y, Cai Q (2004). Application of StarburstTM PAMAM dendrimers as DNA carriers in vitro. Prog Biochem Biophys, 31(9): 804-811.

    ……